ReviewThe Saudi dental journal2025
What is the impact of stress on the development of molar incisor hypomineralization (MIH): a systematic review.
Review in The Saudi dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Family structure and sociodemographic factors associated with molar incisor hypomineralization in children.Scientific reports · 2026Observational
- Enamel Defects Among Orphanage Children: A Multi-Country Case-Control Study.International dental journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molar Incisor Hypomineralization (MIH) is a developmental enamel defect that affects permanent first molars (PFMs) and incisors, leading to caries and early tooth loss. This systematic review investigates the literature for the relationship between stress-related factors and the occurrence of MIH. A comprehensive literature search was conducted across PubMed, Cochrane, Scopus, Google Scholar, and BASE. Articles were screened and data extracted using the Rayyan platform for systematic reviews. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Six-studies were included, five examined maternal stress during pregnancy while one on stress experienced during early childhood. Out of them, five reported a significant association between stress and MIH. Given the significant variability in stress assessment methods across studies, we were able to include only two studies in the meta-analysis. Although not statistically significant, the meta-analysis showed a tendency for increased odds of MIH in the presence of stress, with an overall odds ratio of 1.46 (95% CI: 0.66-3.22). These findings suggest a potential association between psychological stress and MIH. However, further research is needed to confirm these results and elucidate the mechanisms involved. Addressing current research limitations will improve study reliability and inform preventive strategies to reduce maternal and early childhood stress, potentially mitigating MIH prevalence.
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Registered trials
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