Evidence map›Paper›PMID 40488909›Full record

ReviewMolecular biology reports2025

NETosis in hypersensitivity disorders.

Manouchehr Fadaee, Reza Aghaei, Niloufar Orooji, Sina Mahdavi, Masoud Lahouty, Shabnam Babaei, Mahdyar Shahizare, Golnaz Mobayen, Armin Ghahremanzadeh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manouchehr FadaeeStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. fadaeem@tbzmed.ac.ir.
Reza AghaeiDepartment of veterinary medicine, Shab.C, Islamic Azad University, Iran, Shabestar.
Niloufar OroojiConnective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sina MahdaviDepartment of Microbiology and Virology, Tabriz University of Medical Sciences, Tabriz, Iran.
Masoud LahoutyPediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shabnam BabaeiDepartment of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahdyar ShahizareDepartment of veterinary medicine, Shab.C, Islamic Azad University, Iran, Shabestar.
Golnaz MobayenPediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Armin GhahremanzadehPediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils are the first cells among the innate and adaptive immune cells, which quickly react to infections, injuries, and disease. Neutrophils have a wide range of antimicrobial proteins that are secreted from the cell through the NETosis process. Neutrophil extracellular traps (NETs) are intricate formations composed of chromatin decondensed and coated with granular and cytosolic proteins. The body's defensive mechanism first identified NETs as critical participants due to their capacity to immobilize and even eliminate germs. Follow-up investigations have shown that these substances have a role in developing numerous diseases, as their significant components harm nearby tissues. Hypersensitivity disorders are characterized by an unregulated and inappropriate immune response to innocuous antigens, resulting in numerous detrimental results. Both excessive NETosis and poor NET clearance contribute to the tissue damage observed in hypersensitivity disorders such as small vessel vasculitis (SVV), systemic lupus erythematosus (SLE), and psoriasis. NETs can also activate T cells to initiate inflammatory reactions and tissue damage. Here, we explore the recent advances in the role of NETosis in the pathogenesis of hypersensitivity disorders.

Indexed as

Extracellular TrapsHypersensitivityNeutrophilsAnimalsHumansImmunity, InnateLupus Erythematosus, SystemicPsoriasisT-LymphocytesAllergyAutoimmune diseaseChronic inflammationHypersensitivity reactionNETosis

Identifiers

PMID40488909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.