Evidence map›Paper›PMID 40488899›Full record

ArticleCalcified tissue international2025

Exploring the Role of FGF7 in Tumor-Induced Osteomalacia. Clinic-Pathologic Analysis in a Patient with a Sino-Nasal Phosphaturic Mesenchymal Tumor.

L Colangelo, F R Di Ciommo, B Palmisano, R Scrivo, M Della Monaca, J Pepe, C Cipriani, C Alessandri, V Valentini, M Riminucci and 3 more

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In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

L Colangelo *Department of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
F R Di Ciommo *Department of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
B PalmisanoDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
R ScrivoDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
M Della MonacaDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, Rome, Italy.
J PepeDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
C CiprianiDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
C AlessandriDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
V ValentiniDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, Rome, Italy.
M RiminucciDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
S MinisolaDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. salvatore.minisola@uniroma1.it.ORCID http://orcid.org/0000-0001-6525-0439
F ContiDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
A CorsiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to the overproduction of Fibroblast Growth Factor 23 (FGF23). Although other phosphate-regulating substances (i.e., "phosphatonins") have been demonstrated to be expressed in tumors associated with TIO, very limited information is available about their circulating levels and clinical significance. Here, we report a patient with a long-standing history of low serum phosphate values due to a sino-nasal phosphaturic mesenchymal tumor (PMT), in which the co-expression of FGF23 and FGF7 was detected in the neoplastic tissue and their serum levels determined before and after surgical tumor excision. The serum level of FGF23 was increased (312.0 pg/mL) before surgery and promptly normalized 24 h after tumor excision. In contrast, the value of FGF7 was high (202.6 pg/mL) before surgery, fell at 24 h after surgery (108.6 pg/mL), increased again after one week (252.0 pg/mL), and finally normalized (33.4 pg/mL) one year later, when also serum phosphate was in the normal range. This is the first sino-nasal PMT in which expression of FGF7 was observed and the first case of TIO in which the serum levels of FGF7 were monitored during the course of the disease (i.e., before and after tumor excision). Even though "phosphatonins" in addition to FGF23 are thought to contribute to the phosphate wasting leading to TIO, the observed increase in FGF7 levels one week after surgery (+ 31.66% compared to the preoperative value), when phosphate levels tended to normalize, may suggest a mild, if ever, phosphaturic effect of FGF7. Further studies are needed to define the mechanisms underlying the different post-surgical time-dependent decrease in the serum levels of FGF23 and FGF7 and the role of FGF7 in patients with TIO and more in general in phosphate homeostasis.

Indexed as

Fibroblast Growth Factor 7MesenchymomaNeoplasms, Connective TissueOsteomalaciaParaneoplastic SyndromesFibroblast Growth Factor-23Fibroblast Growth FactorsHumansFGF23 protein, humanFGF7 protein, humanFibroblast Growth Factor-23Fibroblast Growth Factor 7Fibroblast Growth FactorsFGF23FGF7PhosphatoninsPhosphaturic mesenchymal tumorSino-nasal regionTumor-induced osteomalacia

Identifiers

PMID40488899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.