Evidence map›Paper›PMID 40488852›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Synthesis, characterization, and drug delivery application of carboxymethyl chitosan-CTAB self-assembling.

Lijun Dong, Ge Hong, Xin Zhao, Mengmeng Jiang, Jianrong Wei, Yanyan Li

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lijun DongCollege of Life Sciences, Hebei University, Baoding, Hebei, 071002, China.
Ge HongTianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Xin ZhaoCollege of Life Sciences, Hebei University, Baoding, Hebei, 071002, China.
Mengmeng JiangCollege of Life Sciences, Hebei University, Baoding, Hebei, 071002, China.
Jianrong WeiCollege of Life Sciences, Hebei University, Baoding, Hebei, 071002, China.
Yanyan LiCollege of Life Sciences, Hebei University, Baoding, Hebei, 071002, China. liyanyan203li@163.com.ORCID 0000-0001-8931-3844

Funding

the Key Research and Development Program of Hebei Province 20326511D
6 · The paper itself

Abstract

In this study, self-assembly vesicles based on carboxymethyl chitosan (CMCS) were prepared for insulin delivery. The self-assembly behavior of mixed systems consisting of CMCS and the cetyl trimethyl ammonium bromide (CTAB) was investigated. The resulting CMCS/CTAB vesicles were nearly spherical in shape, with the majority ranging around 100 nm in diameter. The toxicity profile of CMCS/CTAB vesicles was evaluated in vitro via methyl thiazolyl tetrazolium (MTT) assay. The results indicated that the stability of CMCS/CTAB vesicles was enhanced by increasing the degree of substitution (DS) of CMCS or by reducing the molecular weight (MW) of CMCS. Additionally, we observed that vesicle stability improved with decreased temperature. The insulin loading capacity and encapsulation efficiency decreased as the MW increased. Moreover, the loading capacity and encapsulation efficiency increased with the increase of the DS. The release of insulin slowed as the insulin content increased. The increase of MW or DS of CMCS could slow the release of insulin.

Indexed as

Cetrimonium CompoundsChitosanDrug CarriersDrug Delivery SystemsHypoglycemic AgentsInsulinAnimalsCell SurvivalCetrimoniumDrug LiberationMolecular WeightParticle Sizecarboxymethyl-chitosanCetrimoniumCetrimonium CompoundsChitosanDrug CarriersHypoglycemic AgentsInsulinCarboxymethyl chitosanControlled releaseCytotoxicityInsulinStabilityVesicle

Identifiers

PMID40488852

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.