Evidence map›Paper›PMID 40488846›Full record

SynthesisArchives of gynecology and obstetrics2025

Enhancement of angiogenesis and follicular survival using growth factors during ovarian tissue transplantation: a systematic review.

Lixia Zhang, Mei Zhang, Xiaoling Jiang, Min Wang, Haixia Shu, Guanyan Wang, Pingyuan Li, Maoyuan Wu, Wenwen Zhang, Lianli He

Abstract readEditorialSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lixia ZhangDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Mei ZhangDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xiaoling JiangDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Min WangDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Haixia ShuDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Guanyan WangDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Pingyuan LiDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Maoyuan WuDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Wenwen ZhangDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Lianli HeDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. 1744122878@qq.com.

Funding

Guizhou Provincial Administration of Traditional Chinese Medicine QZYY-2024-039Guizhou Provincial Science and Technology Agency Qiankehe Jichu-ZK2022-No.580Health Commission of Guizhou Province GZWKJ2025-097Zunyi Science and Technology Bureau Zunshikehe-HZ2024-No.12
6 · The paper itself

Abstract

The incidence of malignant tumors continues to grow. Still, with the rapid development of various diagnostic and therapeutic techniques, the survival rate of malignant tumors has been improved, and the increased survival rate has introduced the need for fertility preservation therapy for cancer patients. Cryopreservation of ovarian tissue is a relatively new technique that has gained milestones, but because ovarian tissue transplantation is a non-vascular anastomotic free graft, the growth and development of the transplanted ovarian tissue is contingent on the re-establishment of the circulatory system. More than 50% of follicles are lost before neovascularization of the tissue is established after transplantation. In this systematic evaluation, we searched Embase and PubMed databases and included reports of trials using mouse or human ovarian tissue for transplantation in combination with growth factors. Of the 812 articles retrieved, 9 met the criteria. The growth factor applied to transplant ovarian tissue promotes the process of vascular reconstruction, thus enhancing the preservation of follicle and ovarian tissue. The conclusion that growth factors promote the recovery of transplanted ovarian tissue can be drawn from histological analyses of ovarian tissue, the detection of factors responsible for blood vessel formation, and the study of sex hormone levels that indirectly indicate the recovery of ovarian function.

Indexed as

Fertility PreservationIntercellular Signaling Peptides and ProteinsNeovascularization, PhysiologicOvarian FollicleOvaryAngiogenesisAnimalsCryopreservationFemaleHumansMiceIntercellular Signaling Peptides and ProteinsAngiogenesisFollicular survivalGrowth factorsOvarian tissueTransplantation

Identifiers

PMID40488846
PMCPMC12374891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.