Evidence map›Paper›PMID 40488825›Full record

ReviewAdvances in experimental medicine and biology2025

Optimal GVHD Prophylaxis.

Hany Elmariah, Javier Bolaños-Meade

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hany ElmariahMoffitt Cancer Center, Tampa, FL, USA.
Javier Bolaños-MeadeThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA. fbolano2@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graft-versus-host disease (GVHD) limits the curative potential of allogeneic hematopoietic cell transplant (HCT). This immune-mediated disease can result in multisystem organ morbidity, chronic debility, or mortality. Prevention of GVHD is a primary objective when treating patients with allogeneic HCT. While many factors are considered in transplant planning, the choice of GVHD prophylaxis is a critical and modifiable factor that impacts the risk of GVHD. Each regimen is associated with variable GVHD risk, immune reconstitution, infection risk, graft-versus-tumor effect, and drug-related adverse events. Furthermore, the utility of a specific regimen must be considered in the context of the transplant platform such as conditioning regimen and donor choice. In this chapter, we review the current state of GVHD prophylaxis, highlighting the historical standard approach of calcineurin inhibitor-based regimens, as well as the emerging standard of post-transplant cyclophosphamide.

Indexed as

Calcineurin InhibitorsGraft vs Host DiseaseHematopoietic Stem Cell TransplantationImmunosuppressive AgentsTransplantation ConditioningCyclophosphamideHumansTransplantation, HomologousCalcineurin InhibitorsCyclophosphamideImmunosuppressive AgentsAbataceptAntithymocyte globulinCalcineurin inhibitorGVHDGVHD prophylaxisHaploidenticalMatched donorMethotrexateMismatched unrelatedPost-transplant cyclophosphamide

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.