ArticleTropical animal health and production2025
Improving intestinal barrier function and intestinal microbiome of weaned piglets fed a low-protein diet through tryptophan and N-Acetylglutamic acid supplementation.
Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tryptophan supplementation in low-protein diets of sows during late gestation and lactation: Effects on sow performance and piglet growth.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health.Frontiers in veterinary science · 2026Review
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Authors and funding
7 authors.
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Abstract
The research aimed to evaluate how incorporating NAG and Trp into a low-protein diet affects intestinal functions and alterations in the microbiota, ultimately focusing on enhancing the growth and stress resistance of weaned piglets aged 3-4 weeks.A total of 120 weaned piglets were categorized into five distinct groups: a control group (CON), a low-protein diet group (LP), a low-protein diet group with 0.2% N-acetylglutamic acid (LP + NAG), a low-protein diet group with 0.2% tryptophan (LP + Trp), and a low-protein diet group with 0.2% N-acetylglutamic acid and 0.2% tryptophan (LP + NAG + Trp). The results revealed that the LP + NAG + Trp group exhibited a higher feed-to-gain ratio and improved growth performance, with significantly greater average daily gain and feed intake than the control group. Antioxidant capacity was enhanced, as indicated by elevated levels of catalase and glutathione peroxidase. The expression of tight junction proteins ZO-1 and claudin-1 increased, strengthening the intestinal barrier. Additionally, immunoglobulin levels and the abundance of actinomycetes in the gut microbiota rose, indicating improved immune function and gut health.The increased digestive capacity of the intestine may be linked to the growth in the population of actinomycetes, which is attributed to the combined addition of the NAG + Trp group.
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Registered trials
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