Evidence map›Paper›PMID 40488621›Full record

ArticleJournal of virology2025

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution.

Charles S P Foster, Gregory J Walker, Tyra Jean, Maureen Wong, Levent Brassil, Sonia R Isaacs, Yonghui Lyu, Stuart Turville, Anthony Kelleher, William D Rawlinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charles S P FosterSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.ORCID 0000-0002-6700-3746
Gregory J WalkerSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.ORCID 0000-0003-0044-1394
Tyra JeanSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Maureen WongSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Levent BrassilSchool of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.
Sonia R IsaacsSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Yonghui LyuSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Stuart TurvilleKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Anthony KelleherKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
William D RawlinsonSerology and Virology Division (SAViD), NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.ORCID 0000-0003-0988-7827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding viral evolutionary dynamics is crucial to pandemic responses, prediction of virus adaptation over time, and virus surveillance for public health strategies. Whole-genome sequencing (WGS) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has enabled fine-grained studies of virus evolution in the human population. Serial passaging

Indexed as

COVID-19Evolution, MolecularSARS-CoV-2AnimalsChlorocebus aethiopsGenome, ViralHumansMutationSerial PassageSpike Glycoprotein, CoronavirusVero CellsWhole Genome SequencingSpike Glycoprotein, Coronavirusbioinformaticsmutational studiesSARS-CoV-2serial passagingvirologywhole-genome sequencing

Identifiers

PMID40488621
PMCPMC12282192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.