Evidence map›Paper›PMID 40488537›Full record

ReviewmBio2025

Advancements in single-cell techniques for examining the HIV reservoir: pathways to a cure.

Nokuzola Mbhele, Benjamin Chimukangara, Lynn Tyers, Frank Maldarelli, Andrew D Redd

Abstract readReview
In one paragraph

Review in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nokuzola MbheleDivision of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3270-0197
Benjamin ChimukangaraCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.ORCID 0000-0002-8391-4531
Lynn TyersDivision of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0535-9165
Frank MaldarelliHIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health Bethesda, Bethesda, Maryland, USA.ORCID 0000-0002-3062-5250
Andrew D ReddDivision of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4651-1423

Funding

Maximizing the success of HIV+ to HIV+ kidney transplantation in South AfricaU01AI152153 · NIAID · UNIVERSITY OF CAPE TOWN · PI MULLER, ELMI · 2020 to 2024
$900k
HHS | NIH | Intramural Research Program (IRP)National Research Foundation (NRF) PSTD23041793939NHLBI NIH HHSNIAID NIH HHS U01 AI152153U.S.-South Africa Program for Collaborative Biomedical Research 1U01AI152153-01
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) is largely incurable, due to the presence of a viral reservoir, which primarily consists of resting CD4

Indexed as

HIV-1HIV InfectionsSingle-Cell AnalysisVirus LatencyCD4-Positive T-LymphocytesHumansMacrophagesProvirusesVirus IntegrationHIV-1HIV-1 reservoirHIV curesingle-cell

Identifiers

PMID40488537
PMCPMC12239569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.