ArticleMicrobiology spectrum2025
The expression of fungal CotH, human glucose-regulated protein 78 (GRP78), and predicted miRNAs in macrophages and diabetic mice infected with
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Molecular Mechanisms of Mucormycosis Pathogenesis: Host-Pathogen Interactions and Immune Evasion.Pathogens (Basel, Switzerland) · 2026Review
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9 authors.
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Abstract
The spore coat protein homolog (CotH) has been identified among virulence factors of Mucorales that mediate fungal invasion by glucose-regulated protein 78 (GRP78) ligand on endothelial cells. The aim of this study was to examine the gene expressions of spore coat protein homolog 3 (CotH3) and GRP78, along with their target miRNAs, in infected human macrophages, mice models, and mucormycosis patients. To assess changes in the relative expressions of the GPR78 and CotH3 genes, this study used the real-time quantitative PCR method to quantify their target miRNAs in macrophages derived from human monocytes (monocyte-derived macrophages [MDMs]), mice models, and sinus tissue from diabetic patients with mucormycosis. In this study, expressions of GRP78 and CotH3 genes were elevated in infected MDMs and non-diabetic Balb/c mice infected with IMPORTANCE: The research delves into the intricate gene expression patterns of CotH3, a homolog of CotH, and GRP78 in human macrophages, mice models, and diabetic patients afflicted with mucormycosis. The study's findings underscore the pivotal role of diabetes in the host-pathogen interaction, revealing that diabetic conditions amplify the expression of the GRP78 gene, thereby escalating the risk of fungal invasion and growth. This research paper is crucial as it sheds light on the intricate mechanisms underlying mucormycosis infection and underscores the heightened vulnerability of diabetic individuals. By elucidating the roles of CotH3 and GRP78 in the infection process, the study contributes to a deeper understanding of mucormycosis pathogenesis and paves the way for the development of targeted therapeutic strategies.
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