Evidence map›Paper›PMID 40488428›Full record

ArticleEpigenomics2025

DNMT1/MTTP axis promotes gastritis progression during

Chunli Tang, Fanlai Meng, Renjie Li, Meimei Ma, Meiling Zhu, Chunfang Xu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunli TangDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Fanlai MengDepartment of Pathology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, China.
Renjie LiDepartment of Clinical Laboratory, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, China.
Meimei MaDepartment of Pathology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, China.
Meiling ZhuDepartment of Gastroenterology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, China.
Chunfang XuDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsSprague-Dawley rats and gastric epithelial cell line were infected with H. pylori to build CAG model. The mRNA and protein levels of DNA methyltransferase 1 (DNMT1), MTTP, and glutathione peroxidase 4 (GPX4) were measured by quantitative real-time PCR (RT-qPCR) and western blotting, respectively. Moreover, the localization of DNMT1 and MTTP was detected via immunohistochemistry. Furthermore, the pathological changes of gastric tissue were analyzed by HE staining.

resultsThe MTTP expression was downregulated in CAG. Moreover, overexpression of MTTP in gastric epithelial cells could suppress the inflammatory response induced by

conclusionDNMT1 downregulated the MTTP expression through methylation, and thus mediate inflammasome-ferroptosis processes via GPX4 in the

Indexed as

Carrier ProteinsDNA (Cytosine-5-)-Methyltransferase 1FerroptosisGastritisGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsCell LineDisease ProgressionDNA MethylationHumansMaleRatsRats, Sprague-DawleyCarrier ProteinsDNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, ratglutathione peroxidase 4, ratPhospholipid Hydroperoxide Glutathione Peroxidasechronic atrophic gastritisDNMT1ferroptosisH. pyloriMTTP

Identifiers

PMID40488428
PMCPMC12233874

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