Evidence map›Paper›PMID 40488330›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Amplifying Anti-Tumor Immune Responses via Mitochondria-Targeting Near-Infrared Photodynamic Therapy.

Cheng-Ao Li, Junjie Nan, Qingxuan Ye, Bingzhu Zheng, Xiaomeng Dai, Jingya Li, Feng Wang, Huimin Ma, Yu Cheng, Jian Ruan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. The Immune Microenvironment in Liver Cancer: From Analysis to Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cheng-Ao LiState Key Laboratory of Silicon and Advanced Semiconductor Materials, Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, China.
Junjie NanDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Key Laboratory of Minimally Invasive Technique and Precision Medicine, Zhejiang University, Hangzhou, 310016, China.
Qingxuan YeDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Key Laboratory of Minimally Invasive Technique and Precision Medicine, Zhejiang University, Hangzhou, 310016, China.
Bingzhu ZhengDepartment of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Xiaomeng DaiDepartment of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Jingya LiState Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou, 014030, China.
Feng WangState Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou, 014030, China.
Huimin MaState Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou, 014030, China.
Yu ChengState Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou, 014030, China.
Jian RuanDepartment of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Weijia FangDepartment of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Peng ZhaoDepartment of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Renren DengState Key Laboratory of Silicon and Advanced Semiconductor Materials, Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0001-8213-6304
Dong CenDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Key Laboratory of Minimally Invasive Technique and Precision Medicine, Zhejiang University, Hangzhou, 310016, China.ORCID https://orcid.org/0009-0006-9161-253X

Funding

Fundamental Research Funds for the Central Universities 2024FZZX02-01-08Fundamental Research Funds for the Zhejiang Provincial Universities 2024FZZX03-02-01National Key Research and Development Program of China 2023YFB3508300National Natural Science Foundation of China 521732908National Natural Science Foundation of China 82102903National Natural Science Foundation of China T2122003Zhejiang Medical Health Science and Technology Program 2023RC031Zhejiang Medical Health Science and Technology Program 2025KY080Zhejiang Provincial Natural Science Foundation of China LMS25H160008Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program 2025ZL392
6 · The paper itself

Abstract

Pro-inflammatory photodynamic therapy (PDT) holds immense potential to ignite robust and long-lasting systemic anti-tumor immune responses. However, the limited penetration depth of conventional ultra violet (UV)-visible irradiation and the tumor hypoxia microenvironment significantly constrain the efficacy of immune-regulatory PDT. Here, a mitochondria-targeting enhanced nanoplatform (NZ

Indexed as

Liver NeoplasmsMitochondriaPhotochemotherapyAnimalsCell Line, TumorHumansInfrared RaysMicePhotosensitizing AgentsTumor MicroenvironmentPhotosensitizing Agentsanti‐tumor immunitynear‐infraredorthotopic liver tumorphotodynamic therapy

Identifiers

PMID40488330
PMCPMC12412487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.