ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Optimal sleep timing revealed: a new perspective on reducing all-cause mortality and cardiovascular disease-cause mortality in older adults.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Association of obstructive sleep apnoea with exercise capacity and mortality in a population-based study: results of SHIP-TREND.ERJ open research · 2026Article
- Now is the time to prioritize sleep timing for cardiovascular health.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
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10 authors.
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Abstract
STUDY
objectivesIn addition to sleep duration, sleep timing is another important but significantly understudied sleep characteristic that may be closely associated with cardiovascular disease (CVD) mortality. To investigate optimal sleep timing, we assessed the associations of sleep timing with all-cause and CVD mortality in a large sample of older adults.
methodsThis prospective cohort study included 18,129 adults (median age = 65 years) from Guangzhou Biobank Cohort Study, recruited during 2008-2012 and followed up until July 2022. Participants' sleep timing (early, intermediate, and late) was defined by the midpoint between bedtime and wake time. Four CVD susceptibility single-nucleotide polymorphisms were used to calculate the genetic risk score.
resultsDuring a median follow-up of 12.4 years with 213,534 person-years, 2,997 deaths occurred. Compared with the intermediate group, both early and late midpoint groups were associated with a higher risk of all-cause mortality (adjusted hazard ratio = 1.18, 95% confidence interval = 1.07-1.30; and adjusted hazard ratio = 1.13, confidence interval = 1.01-1.26, respectively). Restricted cubic spline curves indicated U-shaped associations of sleep at midpoint, bedtime, and wake time with all-cause and CVD mortality (all
conclusionsFor the first time, we identified U-shaped associations of sleep timing with all-cause and CVD mortality by identifying the specific sleep timing points associated with the lowest mortality risk, explicitly from 11:00 pm to 6:00 am. CITATION: Wang J, Li YR, Jiang CQ, et al. Optimal sleep timing revealed: a new perspective on reducing all-cause mortality and cardiovascular disease-cause mortality in older adults.
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