Evidence map›Paper›PMID 40488205›Full record

ArticleFrontiers in neurology2025

Potential correlation between dental caries and intracranial aneurysm: an innovative prognostic marker for intracranial aneurysm development.

Jia Sun, Siming Gui, Dachao Wei, Jia Jiang, Jun Lin, Wentao Gong, Huijian Ge, Youxiang Li

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Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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8 authors.

Jia Sun *Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Department of the First Clinical Division, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.
Siming Gui *Department of Neurointerventional Surgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Dachao WeiDepartment of Neurointerventional Surgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jia JiangDepartment of Neurointerventional Surgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jun LinDepartment of Neurointerventional Surgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Wentao GongDepartment of Interventional Neuroradiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huijian GeDepartment of Neurointerventional Surgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Youxiang LiBeijing Engineering Research Center for Interventional Neuroradiology, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The prevalence of intracranial aneurysm (IA) in the population is approximately 3-7%, with a rupture mortality rate as high as 40%. Identification of risk factors for IA occurrence and provision of targeted preventive and therapeutic measures are crucial for clinical diagnosis of IA. Dental caries is a common oral disease that affects the global population. In this study, we aimed to explore the potential connection between dental caries and the incidence of IA. Methods: We conducted a single-center retrospective 1:1 matched case-control study to assess the correlation between dental caries and the occurrence of IA among 230 participants. Participants were categorized into IA and non-IA groups. All participants underwent cerebral digital subtraction angiography or magnetic resonance angiography, as well as oral assessment. Using binary logistic regression analyses, we examined whether presence of dental caries was correlated with the occurrence of IA. Results: Compared with the non-IA group, the IA group exhibited a greater prevalence of dental caries (90.44% vs. 56.52%) and a greater prevalence of history of root canal treatment (73.91% vs. 48.70%). Multiple logistic regression analysis revealed a significance between the presence of dental caries (OR: 4.14, 95% CI: 1.35-12.66) and IA occurrence. Also, the history of root canal treatment (OR: 2.03, 95% CI: 1.09-3.79) were significantly associated with IA occurrence (all Conclusion: Dental caries was significantly associated with the incidence of IA. Cariogenic bacteria may enter the systemic circulation through pulp, potentially leading to pathological changes in normal cerebral blood vessels, such as the development of IA.

Indexed as

dental cariesintracranial aneurysmoral infectionroot canal treatmentsubarachnoid hemorrhage

Identifiers

PMID40488205
PMCPMC12140992

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