Evidence map›Paper›PMID 40488179›Full record

ArticleBrain communications2025

Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders.

Sterre C M de Boer, Lina Riedl, Simon Braak, Chiara Fenoglio, David Foxe, James Carrick, Ramón Landin-Romero, Sophie Matis, Zac Chatterton, Ishana Rue and 14 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Depression and apathy in frontotemporal dementia: a short assessment of facts and outlook.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Sterre C M de BoerAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.ORCID https://orcid.org/0000-0002-9595-7221
Lina RiedlDepartment of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, München 80333, Germany.
Simon BraakDepartment of Psychiatry, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Chiara FenoglioDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milano, MI 20133, Italy.
David FoxeFaculty of Science, School of Psychology, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-0299-3344
James CarrickFaculty of Science, School of Psychology, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-1392-8919
Ramón Landin-RomeroFaculty of Medicine and Health, School of Health Sciences, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-0485-8090
Sophie MatisFaculty of Medicine and Health, School of Health Sciences, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.
Zac ChattertonFaculty of Medicine and Health, School of Health Sciences, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.
Ishana RueDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Verdun, QC H4H 1R3, Canada.
Marie-Paule E van EngelenAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Jay L P FieldhouseAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Mardien OudegaAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Sigfried N T M SchouwsAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Welmoed A KrudopAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Argonde C van HartenAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Flora H DuitsAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Sven J van der LeeAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Daniela GalimbertiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milano, MI 20133, Italy.
Janine Diehl-SchmidDepartment of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, München 80333, Germany.
Glenda M HallidayFaculty of Medicine and Health, School of Health Sciences, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-0422-8398
Simon DucharmeDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Verdun, QC H4H 1R3, Canada.ORCID https://orcid.org/0000-0002-7309-1113
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam 1081HZ, The Netherlands.
Olivier PiguetFaculty of Science, School of Psychology, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia.ORCID https://orcid.org/0000-0002-6696-1440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sporadic behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed as late-onset primary psychiatric disorder (PPD) due to overlapping symptoms and lack of biomarkers. We aimed to identify clinical features that distinguish sporadic bvFTD from PPD. Multi-centre baseline data were retrospectively retrieved and categorized into neuropsychological domains. Logistic regression models and receiver operating characteristic curves were conducted to determine discriminators. Data from 508 sporadic bvFTD and 152 PPD cases were included. Higher scores in cognitive screening [odds ratio (OR): 1.23], facial emotion processing (OR: 1.69), episodic memory (OR: 1.09), animal fluency (OR: 1.17), working memory (OR: 1.18), letter fluency (OR: 1.17) and depressive symptoms (OR: 7.41) were significantly associated with PPD (all

Indexed as

diagnosticsfrontotemporal dementiapsychiatry

Identifiers

PMID40488179
PMCPMC12141780

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.