ArticleMethodsX2025
Modified QuEChERS for antiepileptic drugs detection in forensic toxicology.
Article in MethodsX, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to concurrently assess the blood concentrations of antiepileptic drugs including phenobarbital, carbamazepine, primidone, phenytoin in post-mortem samples through the application modified QuEChERS extraction. The serum samples were extracted and then purified using magnesium sulfate, PSA, and C18 sorbents and subsequently analyzed using HPLC/UV. One influencing parameter on the extraction process was the pH of sample. Extraction recoveries were in the range of 42-97 % for all analytes. The findings reveal that the QuEChERS method offers a higher extraction efficiency, yielding cleaner samples with greater purity and preferred choice for drug analysis in forensic toxicology. The results showed that the proposed technique has a good analytical efficiency and the accuracy of work is in the average range of 70-85 %. The equation of linear calibration curve was obtained with regression coefficient > 0.99. Detection limits were in the range of 0.21-0.38 ng/mL.•This method is inexpensive and fast for determination of antiepileptic drugs in serum•This method has high thought of sample determination.•This method is green chemistry method.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.