Evidence map›Paper›PMID 40488145›Full record

ArticleFrontiers in physiology2025

Reduction in myofilament Ca

Paulina Langa, Angelie Bacon, Chad M Warren, Shamim A K Chowdhury, Monika Halas, Aurelia A Fernandes, Mark D McCauley, Paul H Goldspink, R John Solaro, Beata M Wolska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paulina LangaDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Angelie BaconDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Chad M WarrenDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Shamim A K ChowdhuryDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Monika HalasDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Aurelia A FernandesDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Mark D McCauleyCenter for Cardiovascular Research, College of Medicine, University of Illinois, Chicago, IL, United States.
Paul H GoldspinkDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
R John SolaroDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.
Beata M WolskaDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, IL, United States.

Funding

Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility and Atrial FibrillationR01HL151508 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCCAULEY, MARK D · 2020 to 2024
$3.2M
Signaling To and From the Vascular/Endothelial Compartment and Progression of HCM Linked to Sarcomere MutationsR01HL158634 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOLDSPINK, PAUL H, SOLARO, R JOHN · 2022 to 2025
$3.1M
Acquisition of a Q-Exactive HF Mass SpectrometerS10OD027016 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2019 to 2019
$600k
NHLBI NIH HHS R01 HL151508NHLBI NIH HHS R01 HL158634NIH HHS S10 OD027016
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic disease caused by mutations in sarcomeric proteins. Mutations in sarcomeric proteins that give rise to cardiomyopathies produce abnormalities in the biophysical properties of the sarcomere that are propagated beyond the cardiac myocyte. In this study, we evaluated the hypothesis that early desensitization of myofilament Ca

Indexed as

coronary flowfibrosishypertrophic cardiomyopathymyofilament Ca2+ sensitivitythin filamentsYAP signaling

Identifiers

PMID40488145
PMCPMC12141004

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.