Evidence map›Paper›PMID 40488127›Full record

ArticlebioRxiv : the preprint server for biology2025

Role of IL10 signaling in the circadian control of host response to Influenza infection.

Kaitlyn Forrest, Martina Towers, Oindrila Paul, Hyeonbin Cho, Mahendra V Padmini, Amruta Naik, Haeum Karrisa Lim, Yasmine Issah, Hitesh Deshmukh, Michael C Abt and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Kaitlyn ForrestORCID 0000-0002-8950-6563
Martina TowersORCID 0000-0001-8919-0792
Oindrila Paul
Hyeonbin Cho
Mahendra V PadminiORCID 0000-0001-8726-8066
Amruta NaikORCID 0000-0003-0673-2643
Haeum Karrisa Lim
Yasmine IssahORCID 0000-0002-2314-9807
Hitesh DeshmukhORCID 0000-0001-9632-164X
Michael C AbtORCID 0000-0002-7351-2061
Kristin HudockORCID 0000-0001-5429-3687
Gregory R GrantORCID 0000-0002-0139-7658
Thomas G BrooksORCID 0000-0002-6980-0079
Shaon SenguptaORCID 0000-0001-5237-3835

Funding

Mechanistic evaluation of the role of circadian rhythms in acute lung injury and subsequent recoveryR01HL155934 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI SENGUPTA, SHAON · 2021 to 2025
$2.9M
NHLBI NIH HHS R01 HL155934
6 · The paper itself

Abstract

We have previously demonstrated that the circadian clock regulates the host response to influenza A virus (IAV) infection, conferring a time-of-day-specific protection -infection at dawn resulted in a threefold increase in survival and reduced immunopathology compared to infection at dusk. While IL10 is well-known for its immunoregulatory function, its role in IAV remains unclear, with studies reporting both protective and detrimental effects. Given the diurnal rhythmicity of IL-10 receptor (

Identifiers

PMID40488127
PMCPMC12143876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.