ArticleACS omega2025
Synthesis, Characterization, and Biological Studies of Biopolyurethane-Chitosan Composites Based on Diphenylmethane Diisocyanate and Polyol Derived from Castor Oil for the Development of Biomaterials for Topical Use.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Fabrication of bioprints self-coated with thermally sensitive lactobacilli for CAUTI applications.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2026Article
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Authors and funding
9 authors.
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Abstract
Polyurethanes (PUs) are polymers that have aroused considerable interest in the medical and tissue engineering fields due to their physicochemical properties, such as mechanical and thermal stability, elasticity, and biocompatibility. PUs have been used in the manufacturing of medical devices since the 1960s, such as catheters, artificial hearts, and blood bags. This class of polymers is synthesized from the polyaddition reaction of a polyol (soft segment) with a diisocyanate (hard segment). In view of the tendency to replace polyols derived from fossil resources with those derived from renewable resources, vegetable oils and byproducts of hydroxylated biomass are seen as emerging raw materials for the synthesis of PUs. Raw materials derived from renewable sources include polysaccharides (starch, cellulose, and chitosan) as well as fats and oils of a vegetable and animal origin and have been employed in the creation of biomaterials. Castor oil extracted from the seeds of the plant Ricinus communis is a natural polyol made up of 89% of ricinoleic acid, with an 18-carbon chain and two groups subject to reaction: an unsaturation on carbon 9 and a hydroxyl on carbon 12. Chitosan (CTS) is a polysaccharide in the form of a copolymer formed from 2-amino-2-deoxy-d-glucopyranose and 2-acetamido-2-deoxy-d-glucopyranose units randomly linked by β (1 → 4) glycosidic bonds. Its physicochemical and biological properties make CTS attractive for various applications due to its biocompatibility, biodegradability, mucoadhesivity, and absence of toxicity, along with antimicrobial activity, the ability to coordinate metals, and the ability to serve as a matrix for the loading and controlled release of substances. In the present study, biopolyurethane-chitosan (PUCTS) composites were prepared using the "one-shot method", in which a polyol derived from castor oil was mixed with CTS and then with methylene diphenyl diisocyanate (MDI) in a reaction flask at room temperature with constant stirring. The mixture was degassed and poured into a silicone mold for curing at room temperature. The polymers were characterized by FTIR,
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Registered trials
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