Evidence map›Paper›PMID 40488088›Full record

ArticleACS omega2025

Development and Characterization of Zein/Eudragit Composite Nanoparticles for Insulin Intranasal Delivery.

Felipe Figueiredo Moreira, Jeferson Ziebarth, Tatiane Patricia Babinski, Rubiana Mara Mainardes

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Felipe Figueiredo MoreiraLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Élio Antonio Dalla Vecchia Aveniu, 838, 85040-167 Guarapuava, Paraná, Brazil.
Jeferson ZiebarthLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Élio Antonio Dalla Vecchia Aveniu, 838, 85040-167 Guarapuava, Paraná, Brazil.
Tatiane Patricia BabinskiLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Élio Antonio Dalla Vecchia Aveniu, 838, 85040-167 Guarapuava, Paraná, Brazil.
Rubiana Mara MainardesLaboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Élio Antonio Dalla Vecchia Aveniu, 838, 85040-167 Guarapuava, Paraná, Brazil.ORCID https://orcid.org/0000-0002-4442-2075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels, primarily due to impaired insulin secretion or action. The standard treatment for Type 1 Diabetes Mellitus still involves daily parenteral insulin administration, which presents several challenges including patient discomfort, reduced adherence, and the potential for peripheral hyperinsulinemia. Intranasal administration has emerged as a promising alternative due to the nasal cavity's high vascularization, ease of access, and significant absorption capacity, though certain physiological barriers remain. This study aimed to develop and characterize Zein-Eudragit nanoparticles (NPS) as carriers for insulin (ZEU/INS NPS) intended for intranasal administration. The NPS were prepared using a liquid-liquid dispersion method, and the production process was optimized through a 2

Identifiers

PMID40488088
PMCPMC12138680

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.