ArticleACS omega2025
Lysine Lactylation of Hemoglobin Promotes Oxygen Release in Red Blood Cells.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Thermodynamic Frontiers in Hemoglobin-Inspired Polymer Science for Diagnosis and Modulation of Neurodegenerative Diseases.Cell biochemistry and function · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemoglobin oxygen affinity (HOA) increases during the storage of red blood cells (RBCs), which hinders the oxygen-release efficacy after transfusion. RBCs stored in alkaline preservation solution promote glycolysis and its final product lactate, which is an allosteric regulator of HOA. In recent years, lactylation has been widely studied, and the degree of lactylation is positively associated with the lactate concentration. However, it is unclear whether lactate can participate in the allosteric regulation of HOA via lactylation when lactate accumulates to a certain level during RBC storage in alkaline preservation solutions. Therefore, we prepared preservation solutions with the same formulation but different pH values and investigated the changes in P
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Registered trials
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