Evidence map›Paper›PMID 40488021›Full record

ArticleACS omega2025

Anti-

Ivanildo A Brito, Matheus E Rosa, Elodie Boisselier, Vanessa Albuquerque, Andre G Tempone, Luciano Caseli, João Henrique G Lago

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trypanocidal Activity of Dual Redox-Active Quinones:Pathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ivanildo A BritoCenter of Natural and Human Sciences, Federal University of ABC, 09210-170 Santo Andre, SP, Brazil.
Matheus E RosaDepartment of Chemistry, Federal University of São Paulo, 09972-270 Diadema, SP, Brazil.
Elodie BoisselierFaculty of Medicine, Université Laval, Quebec City G1 V 0A6, Quebec, Canada.ORCID https://orcid.org/0000-0001-8281-5235
Vanessa AlbuquerquePhysiopathology Laboratory, Butantan Institute, 05503-900 São Paulo, SP, Brazil.
Andre G TemponePhysiopathology Laboratory, Butantan Institute, 05503-900 São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-2559-7344
Luciano CaseliDepartment of Chemistry, Federal University of São Paulo, 09972-270 Diadema, SP, Brazil.ORCID https://orcid.org/0000-0002-1177-8454
João Henrique G LagoCenter of Natural and Human Sciences, Federal University of ABC, 09210-170 Santo Andre, SP, Brazil.ORCID https://orcid.org/0000-0002-1193-8374

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease, a parasitic disease caused by the protozoan Trypanosoma cruzi, is an important health problem affecting more than 8 million people worldwide. The only available treatments, benznidazole and nifurtimox, display high toxicity and reduced efficacy in the chronic phase of the disease. To find new natural products with anti-T. cruzi activity, the CH

Identifiers

PMID40488021
PMCPMC12138661

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.