Evidence map›Paper›PMID 40487967›Full record

ArticleWorld journal of gastrointestinal oncology2025

Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer.

Hyehyun Jeong, Yousun Ko, Kyung Won Kim, Ji Sung Lee, Seyoung Seo, Sun Young Kim, Yong Sang Hong, Jeong Eun Kim, Tae Won Kim

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Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hyehyun JeongDepartment of Oncology, Asan Medical Center, Seoul 05505, South Korea.
Yousun KoBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, South Korea.
Kyung Won KimDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Ji Sung LeeClinical Research Center, Asan Medical Center, Asan Medical Center, Seoul 05505, South Korea.
Seyoung SeoDepartment of Oncology, Asan Medical Center, Seoul 05505, South Korea.
Sun Young KimDepartment of Oncology, Asan Medical Center, Seoul 05505, South Korea.
Yong Sang HongDepartment of Oncology, Asan Medical Center, Seoul 05505, South Korea.
Jeong Eun KimDepartment of Oncology, Asan Medical Center, Seoul 05505, South Korea. jeongeunkim@amc.seoul.kr.
Tae Won KimDepartment of Oncology, Asan Medical Center, Seoul 05505, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with metastatic colorectal cancer, chemotherapy may lead to changes in body composition, including skeletal muscle quantity and quality, and body fat area and distribution. Longitudinal follow-up data in a homogeneous population are required to understand these changes better.

aimTo comprehensively evaluate changes in body composition and their prognostic value in patients with metastatic colorectal cancer undergoing palliative chemotherapy.

methodsThis retrospective study included patients with recurrent or metastatic colorectal cancer who received palliative chemotherapy between 2008 and 2017. Computed tomography scans were analyzed at multiple time points (before each new chemotherapy regimen and after discontinuing all chemotherapy). Body composition was analyzed from each scan using artificial intelligence software (AID-UTM, iAID Inc.), and its association with survival was evaluated through time-dependent Cox regression to adjust for time-varying effects.

resultsThis analysis included 1805 patients, with a median age at diagnosis of 57 years, and 62% were male. At first-line chemotherapy initiation, 4.7%, 30.9%, 36.5%, and 37.1% of the patients had sarcopenia, myosteatosis, and visceral and subcutaneous obesity, respectively. During treatment, approximately 54.5% of the patients experienced significant changes in body composition, with 9.1% and 19.2% developing new sarcopenia and myosteatosis, respectively. Sarcopenia and myosteatosis were associated with poorer survival outcomes [hazard ratio (HR) for sarcopenia, 2.55 (95%CI: 2.06-3.16,

conclusionAbnormalities and body composition changes were frequently observed during palliative chemotherapy for advanced colorectal cancer; myosteatosis was common. Comprehensive body composition assessment offers valuable prognostic insights without requiring additional testing.

Indexed as

Artificial intelligenceBody compositionChemotherapyDeep learningMetastatic colorectal cancerMyosteatosisObesityPalliative systemic treatmentSarcopenia

Identifiers

PMID40487967
PMCPMC12142264

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