ArticleWorld journal of gastrointestinal oncology2025
Comparison of dynamic contrast-enhanced-magnetic resonance imaging parameters and serum markers in preoperative rectal cancer evaluation: Combined diagnostic value.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combined imaging and serum biomarkers in CEUS-guided microwave ablation for hepatocellular carcinoma: A meta-analysis.Frontiers in oncology · 2025Pooled it
- Contrast-enhanced MRI improves diagnostic accuracy in stage Tis-T1 rectal cancer: a head-to-head comparison with endorectal ultrasound.European radiology · 2026Article
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4 authors.
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Abstract
backgroundRectal cancer requires accurate preoperative assessment of T stage and differentiation grade for treatment planning. Traditional imaging and serum markers have limitations in diagnostic accuracy.
aimTo evaluate the predictive value of dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) parameters and serum biomarkers [carbohydrate antigen (CA) 19-9, CA125] for determining T stage and differentiation grade in rectal cancer.
methodsWe conducted a retrospective review of clinical data from 126 patients who were pathologically diagnosed with rectal cancer between January 2021 to June 2024. Each patient underwent DCE-MRI scans and serum tests for CA19-9 and CA125. Receiver operating characteristic curves were utilized to assess the diagnostic value of DCE-MRI parameters, including volume transfer constant (Ktrans), rate constant (Kep), and volume fraction of extravascular extracellular space (Ve), as well as serum biomarkers for staging and grading rectal cancer. The DeLong test algorithm was employed to evaluate differences in diagnostic performance among the various indicators.
resultsThere were statistically higher levels of Ktrans, Ve, CA19-9, and CA125 serum concentrations of patients with advanced T stages and on poorly differentiated tumors than that in patients with low stages and moderate to high differentiation (
conclusionThe combined application of DCE-MRI functional parameters and serum tumor markers can significantly improve the diagnostic accuracy of T staging and differentiation degree of rectal cancer, providing a new approach to improve the preoperative assessment system of rectal cancer. This combined diagnostic model has important clinical application value, but further validation is needed through large-scale multicenter studies.
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