ArticleWorld journal of gastrointestinal oncology2025
Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundColorectal cancer (CRC) is a major cause of cancer-related mortality, with limited therapeutic options for advanced stages. Simvastatin, primarily used to lower cholesterol, has shown potential as an anticancer agent. It may exert its effects by inhibiting
aimTo study the effects of simvastatin on the function of colon cancer cells and to uncover the underlying mechanisms.
methodsNCM460, HCT-116, and SW620 cell lines were used for
resultsSimvastatin dose-dependently inhibited the proliferation and migration of HCT-116 and SW620 cells while promoting apoptosis. It downregulated Ki-67, proliferating cell nuclear antigen,
conclusionSimvastatin effectively inhibited the proliferation and migration of colon cancer cells and promoted apoptosis through the modulation of key targets, such as
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