ReviewRegenerative therapy2025
Lineage plasticity and reprogramming of epithelial cells during tissue injury and regeneration-lessons from the lineage plasticity of hepatocytes and cholangiocytes induced by liver injury.
Review in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Adipose-Derived Stem Cell Treatment Induces Early-Term Hes1 Upregulation in a Sox9- and Notch1-Independent Manner in a Rat Model of Bile Duct Ligation.Biomedicines · 2026Article
- Notch signaling in liver diseases: mechanistic insights and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aside from successfully generating induced pluripotent stem cells from somatic cells, "reprogramming of differentiated cells" is a major technique for obtaining any type of target cells in vitro and in vivo by introducing critical transcription factors and using chemical compound combinations. In addition to these technical aspects, the physiological relevance of reprogramming has been extensively investigated, as growing evidence suggests that cellular reprogramming resulting in dedifferentiation or lineage conversion of a specific type of cell is associated with tissue injury and regeneration. We focus on cellular reprogramming in acute and chronically injured livers and summarize the molecular mechanisms governing the lineage transition between two types of liver epithelial cells, hepatocytes, and cholangiocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.