ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2024
Iron Porphyrin-mediated Production of Carbon Monoxide from Phenylpyruvic Acid: From Potential Therapeutic and Diagnostic Use to Physiological Implications.
Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Organic Carbon Monoxide Prodrugs Activated by Endogenous Reactive Oxygen Species for Targeted Delivery.Journal of the American Chemical Society · 2025Article
- Carbon monoxide potentiates the effect of corticosteroids in suppressing inflammatory responses in cell culture.Bioorganic & medicinal chemistry · 2025Article
- A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO.The Journal of organic chemistry · 2024Review
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6 authors.
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Abstract
Because of CO's known endogenous signaling roles and its demonstrated pharmacological activity at low and safe concentrations, there is considerable interest in chemical strategies that allows for generation of carbon monoxide from organic molecules under near-physiological conditions. Along this line, we report our work on studying the ability of iron porphyrin to catalyze CO generation from phenylpyruvic acid (PPA). To utilize this system for potential CO therapeutics and diagnostic applications, an activated charcoal formulation was designed, optimized, and assessed. Among the various iron porphyrin analogs studied, tetrakis(pentafluorophenyl)porphyrin iron (III) (TPFP) immobilized on activated charcoal was found to produce up to 60% CO from PPA. This chemistry could also be utilized in PKU diagnostics for quantification of PPA accumulation in urine. This catalytic conversion allows for the use of CO generation to rapidly quantify PPA concentration in urine samples. Another potential relevance of this CO generation pathway is the extent to which it could undergo
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