ArticleArchives of academic emergency medicine2025
ChatGPT-o1 Preview Outperforms ChatGPT-4 as a Diagnostic Support Tool for Ankle Pain Triage in Emergency Settings.
Article in Archives of academic emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Reasoning-optimised large language models reach near-expert accuracy on board-style orthopaedic exams: A multi-model comparison on 702 multiple-choice questions.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: ChatGPT, a general-purpose language model, is not specifically optimized for medical applications. This study aimed to assess the performance of ChatGPT-4 and o1-preview in generating differential diagnoses for common cases of ankle pain in emergency settings. Methods: Common presentations of ankle pain were identified through consultations with an experienced orthopedic surgeon and a review of relevant hospital and social media sources. To replicate typical patient inquiries, questions were crafted in simple, non-technical language, requesting three possible differential diagnoses for each scenario. The second phase involved designing case vignettes reflecting scenarios typical for triage nurses or physicians. Responses from ChatGPT were evaluated against a benchmark established by two experienced orthopedic surgeons, with a scoring system assessing the accuracy, clarity, and relevance of the differential diagnoses based on their order. Results: In 21 ankle pain presentations, ChatGPT-o1 preview outperformed ChatGPT-4 in both accuracy and clarity, with only the clarity score reaching statistical significance (p < 0.001). ChatGPT-o1 preview also had a significantly higher total score (p = 0.004). In 15 case vignettes, ChatGPT-o1 preview scored better on diagnostic and management clarity, though differences in diagnostic accuracy were not statistically significant. Among 51 questions, ChatGPT-4 and ChatGPT-o1 preview produced incorrect responses for 5 (9.8%) and 4 (7.8%) questions, respectively. Inter-rater reliability analysis demonstrated excellent reliability of the scoring system with interclass coefficients of 0.99 (95% CI, 0.998-0.999) for accuracy scores and 0.99 (95% CI, 0.990-0.995) for clarity scores. Conclusion: Our findings demonstrated that both ChatGPT-4 and ChatGPT-o1 preview provide acceptable performance in the triage of ankle pain cases in emergency settings. ChatGPT-o1 preview outperformed ChatGPT-4, offering clearer and more precise responses. While both models show potential as supportive tools, their role should remain supervised and strictly supplementary to clinical expertise.
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