Evidence map›Paper›PMID 40487896›Full record

ArticleArchives of clinical and biomedical research2025

Sudden Death Induced by Acute Inhalation of Aerosolized Carfentanil.

Xiuping Gao, Jianguo Zhuang, Zikuan Chen, Shan Shi, Fadi Xu

Abstract read
In one paragraph

Article in Archives of clinical and biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Beyond respiratory depression: acute and delayed pulmonary responses following aerosolized fentanyl exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiuping GaoDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
Jianguo ZhuangDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
Zikuan ChenDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
Shan ShiDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
Fadi XuDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.

Funding

Mechanism and Countermeasure of Fentanyl-Induced Sudden DeathR01HL163512 · NHLBI · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI Fadi Xu · 2023 to 2026
$3.7M
Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and DeathR01DA059063 · NIDA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI XU, FADI · 2023 to 2025
$2.0M
NHLBI NIH HHS R01 HL163512NIDA NIH HHS R01 DA059063
6 · The paper itself

Abstract

Bilateral Inhalation of carfentanil (CRF) aerosol could rapidly induce death in humans and CRF aerosol exposure induces respiratory depression in animals; however, the dynamic progression of cardiorespiratory failure leading to sudden death induced by acute CRF aerosol exposure remains unclear. This study aimed to establish a rat model that allows dynamically characterizing the cardiorespiratory failure prior to death following acute exposure to a lethal concentration of CRF aerosol. Two groups of anesthetized and spontaneously breathing rats were exposed to aerosolized vehicle and CRF (4 mg/m

Indexed as

ApneaAtaxic breathingBradycardiaDepressed ventilationHypotension

Identifiers

PMID40487896
PMCPMC12143490

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.