Evidence map›Paper›PMID 40487851›Full record

ArticleGynecologic oncology reports2025

Impact of the COVID-19 pandemic on cancer recurrence rates in patients with ovarian cancer.

Amrita Mukherjee, Natalie Ayoub, Lanfang Xu, Kimberly L Cannavale, Alec D Gilfillan, Elizabeth A Szamreta, Matthew J Monberg, Melissa Hodeib, Chun R Chao

Abstract read
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amrita MukherjeeKaiser Permanente Southern California, Pasadena, CA, USA.
Natalie AyoubAdventist Health White Memorial Medical Center, Los Angeles, CA, USA.
Lanfang XuMedHealth Analytics Inc., Sugar Land, TX, USA.
Kimberly L CannavaleKaiser Permanente Southern California, Pasadena, CA, USA.
Alec D GilfillanKaiser Permanente Southern California, Pasadena, CA, USA.
Elizabeth A SzamretaMerck & Co., Inc., Rahway, NJ, USA.
Matthew J MonbergMerck & Co., Inc., Rahway, NJ, USA.
Melissa HodeibKaiser Permanente Southern California, Riverside, CA, USA.
Chun R ChaoKaiser Permanente Southern California, Pasadena, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus diseases 2019 (COVID-19) pandemic was associated with disruption of oncology care and increased utilization of telehealth. However, the impact of the pandemic on cancer outcomes is under-studied. We evaluated the impact of the COVID-19 pandemic on recurrence rates in ovarian cancer patients in a retrospective cohort study. Women (age ≥ 18 years) diagnosed with stage I-IV epithelial ovarian cancer between 01/01/2017-06/30/2021 at Kaiser Permanente Southern California who received chemotherapy and/or surgery; and achieved complete remission following first-line treatment were included. The pre-pandemic and pandemic periods were defined based on the date of implementation of stay-at-home order in California (03/04/2020). Chart reviews were conducted to determine recurrence within 12 months of remission by physician notes, imaging findings, or CA125 levels. A total of 548 patients were included; 73.4 % and 26.6 % patients were diagnosed during the pre-pandemic and pandemic periods, respectively. About a quarter of the patients had cancer recurrence within 12 months of remission; 25.6 % and 19.2 % of patients diagnosed in the pre-pandemic and pandemic periods had recurrence, respectively (p-value = 0.12). Patients diagnosed during the pandemic were 35 % less likely to have recurrence than those in the pre-pandemic period, after adjusting for age, race/ethnicity, cancer stage, and time to treatment. Additionally adjusting for poly-ADP ribose polymerase (PARP) inhibitors in patients with stage II-IV cancer led to similar findings. In conclusion, ovarian cancer patients diagnosed and treated during the COVID-19 pandemic at KPSC did not have a higher recurrence rate than patients in the pre-pandemic period, despite changes in management approach.

Indexed as

Cancer outcomeCancer recurrenceCOVID-19Ovarian cancerPandemic

Identifiers

PMID40487851
PMCPMC12141953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.