Evidence map›Paper›PMID 40487804›Full record

ArticleOsteoarthritis and cartilage open2025

Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation.

Luke Childress, Landon B Gatrell, Hong Wu, Elisabeth Ferreira, Intawat Nookaew, Ryan M Porter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luke ChildressCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Landon B GatrellCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Hong WuCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Elisabeth FerreiraCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Intawat NookaewCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Ryan M PorterCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI CHARLES A O'BRIEN · 2018 to 2026
$23.0M
Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissuesR01AR075121 · NIAMS · NORTHEASTERN UNIVERSITY · PI BAJPAYEE, AMBIKA GOEL · 2020 to 2025
$2.5M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
Training in Systems Pharmacology and Toxicology (T-SPaT)T32GM150536 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI William E Fantegrossi · 2023 to 2026
$708k
NIAMS NIH HHS R01 AR075121NIGMS NIH HHS P20 GM125503NIGMS NIH HHS T32 GM106999NIGMS NIH HHS T32 GM150536
6 · The paper itself

Abstract

Objective: Cellular senescence has been implicated in the progression of post-traumatic osteoarthritis, but any role in pre-osteoarthritic cartilage repair is unknown. Our objective was to determine whether senescent cells contribute to fibrocartilage repair using a rodent model of marrow stimulation. Design: A 1 ​mm osteochondral defect was generated in the trochlear groove of young adult and middle-aged Lewis rats, modeling the age range when humans receive marrow stimulation. Some rats were treated by intra-articular (IA) injection of senolytic drugs navitoclax or dasatinib plus quercetin. Repair tissue was characterized during the first months after marrow stimulation by histology as well as bulk and single cell transcriptomic analysis. Results: Multiple senescence markers were measured within repair tissue during the first months of repair, in contrast to adjacent, intact articular cartilage. The IA delivery of senolytic drugs reduced p16 Conclusions: Senescent cells, including neochondrocytes, are abundant within inferior repair tissue following marrow stimulation. While their fibrogenic SASP is associated with poor healing, their removal after senescence induction does not improve repair tissue quality, possibly due to the lack of a replacement chondrogenic population.

Indexed as

Articular cartilageBone marrow stimulationCellular senescenceOsteochondral defectSenescence-associated secretory phenotypeSingle cell RNA sequencing

Identifiers

PMID40487804
PMCPMC12143830

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.