ArticleJournal of asthma and allergy2025
Age, Sex, and Symptom-Dependent Variations in Total IgE and Eosinophils in Atopic Patients: A Five-Year Retrospective Study.
Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association of Serum IgE and Peripheral Eosinophilia with Seborrheic Dermatitis: Evidence from a Case-Control Study.Dermatology practical & conceptual · 2026Article
- Allergic Sensitization to Common Ragweed and Mugwort Pollen Allergens: A 6-Year Single-Center Retrospective Analysis.Journal of immunology research · 2026Review
- Type 2 Inflammation in Asthma and COPD: Biomarkers, Clinical Applications, and Targeted Therapies.Journal of inflammation research · 2026Review
- Development of a clinical prediction model for cough variant asthma.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
8 authors.
Funding
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Abstract
Background: Total immunoglobulin E (t-IgE) and eosinophils as central effector molecular and cells are crucial biomarkers for allergic diseases. Age, sex and allergic symptoms may influence these biomarkers and the relationship among t-IgE, eosinophils, and atopic diseases remained unknown. Methods: A five-year retrospective study enrolled 7654 patients with allergic symptoms underwent allergen testing. We collected age, sex, symptoms, and complete blood counts and explored variations in t-IgE and eosinophil across demographic and clinical parameters. Results: Among atopic patients, t-IgE levels peaked in children, decreasing with age, with a slight increase in the elderly, mirroring eosinophil trends. Females consistently exhibited lower t-IgE and eosinophil levels than males, regardless of atopic status. High t-IgE and eosinophils were the most common in patients ≥12 years with respiratory symptoms. Dust mites often caused respiratory symptoms. Egg allergies typically affected the ear, nose, and throat (ENT). Seafood/peanut allergies were linked to skin symptoms. Interestingly, elevated t-IgE and eosinophil levels did not consistently correlate with positive allergen tests. Among atopic patients, 44.5% exhibited normal t-IgE, and 41.4% had normal eosinophils. In the subgroup (22.8%) with both markers normal, more were females (62.5%). Sensitization to allergens like soy, shrimp, mold combination, Artemisia argyi, common ragweed, and willow/aspen/elm may fail to elevate t-IgE and eosinophils. Conclusion: Characteristics such as older age, female, skin and ENT symptoms, and allergens may correlate with lower t-IgE and eosinophils in the allergic populations which means we should pay more attention to these population, even if their t-IgE and eosinophils are normal, the allergen test is necessary for treatment strategies. Clinical Trial Registration: ChiCTR2300067700 (Date of Registration: 2023-01-18).
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