Evidence map›Paper›PMID 40487784›Full record

ArticleBiological psychiatry global open science2025

Association of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders.

Saren H Seeley, Rachel Fremont, Zoe Schreiber, Laurel S Morris, Leah Cahn, James W Murrough, Daniela Schiller, Dennis S Charney, Robert H Pietrzak, M Mercedes Perez-Rodriguez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saren H SeeleyDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Rachel FremontDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Zoe SchreiberDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Laurel S MorrisDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Leah CahnDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
James W MurroughDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Daniela SchillerDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.
Dennis S CharneyDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Robert H PietrzakDepartment of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Health Care System, West Haven, Connecticut.
M Mercedes Perez-RodriguezDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Adriana FederDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Funding

Training the next generation of clinical neuroscientistsT32MH122394 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rene S. Kahn, ANTONIA S NEW · 2020 to 2026
$2.5M
NIMH NIH HHS T32 MH122394NIOSH CDC HHS U01 OH011473
6 · The paper itself

Abstract

Background: Despite their exposure to potentially traumatic stressors, the majority of World Trade Center (WTC) responders-those who worked on rescue, recovery, and cleanup efforts on or following September 11, 2001-have shown psychological resilience, never developing long-term psychopathology. Psychological resilience may be protective against the earlier age-related cognitive changes associated with posttraumatic stress disorder (PTSD) in this cohort. In the current study, we calculated the difference between estimated brain age from structural magnetic resonance imaging (MRI) data and chronological age in WTC responders who participated in a parent functional MRI study of resilience ( Method: WTC responders screened for the absence of cognitive impairment were classified into 3 groups: a WTC-related PTSD group ( Results: Globally, brain aging was decelerated in the Highly Resilient group and accelerated in the PTSD group, with a significant group difference ( Conclusions: Cognitively healthy WTC responders show differences in brain aging related to resilience and PTSD.

Indexed as

Brain agingCognitive agingPTSDResilienceStructural MRIWorld Trade Center responders

Identifiers

PMID40487784
PMCPMC12143172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.