ArticleBiological psychiatry global open science2025
Putative Mechanisms of Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Examined Using Magnetic Resonance Imaging.
Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Electroconvulsive therapy research in India: A scoping review.Indian journal of psychiatry · 2026Review
- Multilevel Neuroimaging Insights Into Electroconvulsive Therapy Mechanisms in Clozapine-Refractory Schizophrenia: A Comparative Perspective With Depression.Biological psychiatry global open science · 2025Article
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Authors and funding
9 authors.
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Abstract
Background: The neural mechanisms of electroconvulsive therapy (ECT) in refractory schizophrenia remain elusive. In the current study, we aimed to identify magnetic resonance imaging (MRI)-derived structural (cortical/subcortical volumes) and functional (resting-state connectivity) brain changes after ECT and their associations with clinical response. Methods: We used an inductive (whole-brain, hypothesis-free) approach to examine structural and functional brain changes and their association with clinical response (positive symptom reduction) in clozapine-refractory schizophrenia ( Results: The inductive approach identified volumetric enhancement in the bilateral amygdalae (Cohen's Conclusions: ECT may drive clinical improvement in refractory schizophrenia by increasing amygdala volumes and reducing posterior cerebellar connectivity. Randomized sham-controlled trials can confirm these findings in the future.
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