Evidence map›Paper›PMID 40487758›Full record

ArticleFrontiers in endocrinology2025

Retrospective analysis of children with 46,XX testicular/ovotesticular DSD: a 10-year single-center experience.

Yan Gong, Xiaoqin Yin, Jing Xu, Yan Li, Qingxu Liu, Shasha Zhou, Fei Wang, Yiqing Lyu, Sheng Guo, Wenyan Huang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan GongDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiaoqin YinDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing XuDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Yan LiDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Qingxu LiuDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Shasha ZhouDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Fei WangDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Yiqing LyuDepartment of Urology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Sheng GuoDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Wenyan HuangDepartment of Nephrology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Pin LiDepartment of Endocrinology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: 46,XX testicular/ovotesticular differences/disorders of sexual development (TDSD/OTDSD) are rare in childhood and exhibit marked distinctions compared to those in adulthood. This study aimed to summarize the clinical characteristics and outcomes of 46,XX TDSD/OTDSD in childhood. Methods: The sexual development characteristics, hormone profiles, chromosomal analysis, fluorescence Results: The median age at initial presentation was 18 months, and external masculinization score(EMS) within the range of 3 < EMS ≤ 6 was more prevalent. There were no statistical differences in hormone levels [luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T)] between the different age groups. Among the 52 children, 4 showed positive Conclusion: Compared to adults, children with 46,XX testicular/ovotesticular DSD were very different.

Indexed as

46, XX Disorders of Sex DevelopmentOvotesticular Disorders of Sex DevelopmentTestisAdolescentChildChild, PreschoolFemaleHumansInfantMaleRetrospective Studies46gender assignmentgeneticsgonadal pathologygonads tumorSRY geneXX testicular/ovotesticular DSD

Identifiers

PMID40487758
PMCPMC12141018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.