Evidence map›Paper›PMID 40487722›Full record

ReviewPhysics and imaging in radiation oncology2025

Uncertainties in outcome modelling in radiation oncology.

Lukas Dünger, Emily Mäusel, Alex Zwanenburg, Steffen Löck

Abstract readReview
In one paragraph

Review in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Maintaining quality of scientific peer-review and publishing inPhysics and imaging in radiation oncology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lukas DüngerOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Emily MäuselOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Alex ZwanenburgOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Steffen LöckOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outcome models predicting e.g. survival, tumour control or radiation-induced toxicities play an important role in the field of radiation oncology. These models aim to support the clinical decision making and pave the way towards personalised treatment. Both validity and reliability of their output are required to facilitate clinical integration. However, models are influenced by uncertainties, arising from data used for model development and model parameters, among others. Therefore, quantifying model uncertainties and addressing their causes promotes the creation of models that are sufficiently reliable for clinical use. This topical review aims to summarise different types and possible sources of uncertainties, presents uncertainty quantification methods applicable to various modelling approaches, and highlights central challenges that need to be addressed in the future.

Indexed as

OutcomeRadiation oncologyStatistical analysesUncertainty modelling

Identifiers

PMID40487722
PMCPMC12145719

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.