Evidence map›Paper›PMID 40487656›Full record

ArticleActa pharmaceutica Sinica. B2025

Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING.

Liming Lin, Jibo Han, Diyun Xu, Zimin Fang, Bozhi Ye, Jinfu Qian, Xue Han, Julian Min, Xiaohong Long, Gaojun Wu and 1 more

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liming LinDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Jibo HanDepartment of Cardiology, the Second Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
Diyun XuDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Zimin FangDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Bozhi YeDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Jinfu QianDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Xue HanChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Julian MinSchool of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou 310014, China.
Xiaohong LongSchool of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou 310014, China.
Gaojun WuDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Guang LiangDepartment of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Doxorubicin (Dox) is an anthracycline drug widely applied in various malignancies. However, the fatal cardiotoxicity induced by Dox limits its clinical application. Post-transcriptional protein modification

Indexed as

AutophagyCardiomyocyteCardiotoxicityDeubiquitinating enzymeDoxorubicinInflammationSTINGUSP13

Identifiers

PMID40487656
PMCPMC12144994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.