Evidence map›Paper›PMID 40487644›Full record

ArticleActa pharmaceutica Sinica. B2025

Prodrug-based combinational nanomedicine remodels lipid metabolism for reinforced ferroptosis and immune activation.

Ling Lin, Zaixiang Fang, Guohao Liu, Yiwei Liu, Zhiqian Li, Dayi Pan, Yunkun Li, Hemi Kang, Xiaoding Shen, Jingyao Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Ultrasound-activated CuJournal of nanobiotechnology · 2026
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  17. Nanomedicines Against Mitochondrial Dysfunction-Induced Metabolic Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ling LinDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Zaixiang FangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Guohao LiuDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Yiwei LiuDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhiqian LiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Dayi PanDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Yunkun LiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Hemi KangCollege of Chemical Engineering, Sichuan University, Chengdu 610041, China.
Xiaoding ShenDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Jingyao ZhangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Qiyong GongDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Kui LuoDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.
Jing JingDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a form of programmed cell death characterized by overwhelmed lipid oxidation, and it has emerged as a promising strategy for cancer therapy. Enhanced ferroptosis could overcome the limitations of conventional therapeutic modalities, particularly in difficult-to-treat tumors. In this study, we developed a dual-modality therapy in nanomedicine by combining paclitaxel (PTX) chemotherapy and pyropheophorbide-a (Ppa) phototherapy. Heparin (HP) was grafted with poly(

Indexed as

Breast cancerCombinational therapyFerroptosisHeparinImmune activationLipid metabolismProdrug-based nanomedicinesROS-responsiveness

Identifiers

PMID40487644
PMCPMC12145006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.