Evidence map›Paper›PMID 40487631›Full record

ReviewClinical medicine insights. Pediatrics2025

Rice Hydrolysate Formula in Infants and Children Allergic to Cow's Milk: A Systematic Review of Evidence.

Khaled Saad, Amir Aboelgheet, Khalid Hashim, Eman F Gad, Anas Elgenidy, Ramez M Odat, Aya Sherif, Ahmed Altaweel, Asmaa B Zahran, Sara K Kamal and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical medicine insights. Pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Khaled SaadDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.ORCID https://orcid.org/0000-0002-8473-6116
Amir AboelgheetDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.
Khalid HashimDepartment of Pediatrics, Faculty of Medicine, Shaqra University, Dawadmi, Saudi Arabia.
Eman F GadDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.
Anas ElgenidyFaculty of Medicine, Cairo University, Egypt.
Ramez M OdatFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Aya SherifFaculty of Medicine, Beni Suef University, Egypt.
Ahmed AltaweelFaculty of Medicine, Alexandria University, Egypt.
Asmaa B ZahranFaculty of Medicine, Menoufia University, Egypt.
Sara K KamalFaculty of Medicine, Cairo University, Egypt.
Abdelrahman ElshimyFaculty of Medicine, Alexandria University, Egypt.
Ahmed SamirFaculty of Medicine, Minia University, Egypt.
Anas KhaledFaculty of Medicine, Al-Azhar University, Damietta, Egypt.
Ahmed IbrahimFaculty of Medicine, Alexandria University, Egypt.
Amira ElhoufeyDepartment of Community Health Nursing, Alddrab University College, Jazan University, Saudi Arabia.
Hamad Ghaleb DailahResearch and Scientific Studies Unit, College of Nursing, Jazan University, Saudi Arabia.
Thamer AlruwailiDepartment of Pediatrics, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Hoda Atef Abdelsattar IbrahimPediatric Clinical Nutrition Division, Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current guidelines recommend extensively hydrolyzed cow's milk protein formulas (EHF) as the first-line treatment for infants diagnosed with cow's milk allergy (CMA). Recently, rice hydrolysate formula (RHF) has emerged as a plant-based alternative with potential advantages in taste, cost-effectiveness, and safety. Objective: Our comprehensive systematic review aimed to evaluate the efficacy of RHF in managing CMA and assess the growth standards of children in short-term follow-up. Methods: We searched PubMed, Scopus, Cochrane, Embase, and Web of Science databases for relevant studies published until May 2024. Eligible studies were selected based on the inclusion criteria. Data extraction covered study characteristics, Results: Seventeen studies, 1695 infants with CMA, and 145 healthy infants were included in the review. Weight-for-age Conclusion: This comprehensive review suggests that RHF can effectively substitute cow's milk formula in managing CMA. These formulas are well tolerated in infants, have varying impacts on growth development, and show promise in reducing atopic symptoms.

Indexed as

cow’s milk protein allergyhydrolysate formularicesystematic review

Identifiers

PMID40487631
PMCPMC12141802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.