Evidence map›Paper›PMID 40487604›Full record

ArticleWorld journal of diabetes2025

Comparisons of various insulin resistance indices for new-onset metabolic syndrome before midlife: The CHIEF cohort study, 2014-2020.

Wei-Nung Liu, Yi-Chiung Hsu, Yen-Po Lin, Kun-Zhe Tsai, Yen-Chen Lin, Pang-Yen Liu, Gen-Min Lin

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Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wei-Nung LiuDepartment of Medicine, Tri-Service General Hospital, Taipei 114, Taiwan.
Yi-Chiung HsuDepartment of Biomedical Sciences and Engineering, Center for Astronautical Physics and Engineering, National Central University, Taoyuan 320, Taiwan.
Yen-Po LinDepartment of Critical Care Medicine, Taipei Tzu Chi General Hospital, New Taipei 23142, Taiwan.
Kun-Zhe TsaiDepartment of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei 104, Taiwan.
Yen-Chen LinDepartment of Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Pang-Yen LiuDepartment of Medicine, Tri-Service General Hospital, Taipei 114, Taiwan.
Gen-Min LinDepartment of Medicine, Tri-Service General Hospital, Taipei 114, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome non-insulin-based insulin resistance (IR) indices have been found to be associated with metabolic syndrome (MetS); however, few cohort studies have compared the capacities of these indices for predicting incident MetS in young adults.

aimTo investigate the associations of various non-insulin-based IR (NI-IR) indices with new-onset MetS in young military personnel.

methodsA total of 2890 armed forces personnel in Taiwan who were aged 18-39 years and did not have MetS at baseline were followed to monitor the incidence of new-onset MetS from 2014 to the end of 2020. Six NI-IR indices, including the metabolic score for IR (METS-IR), triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio, TG glucose (TyG) index, Zhejiang University (ZJU) index, total cholesterol (TC)-to-HDL-C ratio, and alanine transaminase (ALT)-to-aspartate transaminase (AST) ratio, were defined according to specific criteria

resultsDuring a median follow-up of 5.8 years, there were 673 patients with new-onset MetS (23%). All six of the NI-IR indices were significantly and positively associated with incident MetS. In the entire cohort, the greatest AUROC was found for the METS-IR [0.782; 95% confidence interval (CI): 0.762-0.801; all

conclusionThis study suggests that almost all the NI-IR indices are associated with the development of MetS in military young adults. The METS-IR is the strongest predictor of new-onset MetS before midlife.

Indexed as

Cohort studyInsulin resistance indicesMetabolic syndromeYoung adults

Identifiers

PMID40487604
PMCPMC12142194

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