Evidence map›Paper›PMID 40487548›Full record

ArticleWorld journal of clinical cases2025

Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports.

Athena D Myrou, Martha G Spilioti, Anthoula C Tsolaki, Antonis N Frontistis, Christos G Savopoulos

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Athena D MyrouDepartment of Internal Medicine, AHEPA University General Hospital, Thessaloniki 54636, Greece. taniamyrou@gmail.com.
Martha G SpiliotiDepartment of Neurology, AHEPA University General Hospital, Thessaloniki 54636, Greece.
Anthoula C TsolakiDepartment of Neurology, AHEPA University General Hospital, Thessaloniki 54636, Greece.
Antonis N FrontistisDepartment of Neurology, AHEPA University General Hospital, Thessaloniki 54636, Greece.
Christos G SavopoulosDepartment of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University General Hospital, Thessaloniki 54636, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParaneoplastic limbic encephalitis (LE) is an inflammatory condition that affects the limbic system, cerebellum, and peripheral nervous system. It causes a range of symptoms including short-term memory loss, impaired cognitive function, behavioral and psychological disorders, and seizures. Paraneoplastic LE can occur when an immune response is activated due to antibodies targeting gamma-aminobutyric acid (GABA) B receptor (GABABR) interacting with antigens on tumor cells and the nervous system, resulting in tumors primarily as small cell lung carcinoma (SCLC). CASE SUMMARY: We discuss two cases of GABABR antibody-related LE resulting from SCLC. The patients' symptoms were managed with immunotherapy but ended in premature death due to chemotherapy-related complications.

conclusionParaneoplastic syndrome is a notable cause of LE. Early intravenous immunoglobulin therapy may lead to temporary remission.

Indexed as

Case reportEpileptic seizuresGamma aminobutyric acid-B receptor antibodyLimbic encephalitisParaneoplastic encephalitisSmall cell lung carcinoma

Identifiers

PMID40487548
PMCPMC11843069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.