Evidence map›Paper›PMID 40487526›Full record

ArticleFrontiers in public health2025

Health economic evaluation of EV71 vaccination in children under the school-age population in Guangdong Province, China.

Hui Zhang, Jienan Zheng, Danxia Luo, Biao Zeng, Yao Yi, Fen Yang, Lilin Lin, Aiping Deng, Min Kang, Yingtao Zhang

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui ZhangSchool of Medical Business, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Jienan ZhengSchool of Medical Business, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Danxia LuoSchool of Medical Business, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Biao ZengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Yao YiGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Fen YangGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Lilin LinGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Aiping DengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Min KangGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Yingtao ZhangGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aims to evaluate the health economics of hand-foot-mouth disease enterovirus 71 (EV71) vaccination for the population of appropriate age in Guangdong Province. Methods: A SEIR model was constructed, and a group of differential equations was established. The incidence data of HFMD in Guangdong from January to June 2017 were used to fit the model and the basic reproduction value (R Results: The self-funded voluntary EV71 vaccination strategy implemented in Guangdong Province has effectively reduced the disease economic burden of EV71-type HFMD, and the disease economic burden saved during the peak seasonal segment of HFMD in 2017 was $1,080,000. Meanwhile, Scenario 2, 3, and 4 would each result in a cumulative reduction of 6,525, 9,556, and 10,989 confirmed cases, respectively, with net monetary benefits of approximately $6.55 million, $9.59 million, and $11.2 million. The study results show that the current vaccine pricing is not cost-effectiveness, while the vaccine price is lower than $13.15, EV71 vaccination in Guangdong Province has a cost-effectiveness advantage. Conclusion: Vaccination can reduce the incidence of HFMD caused by EV71, which helps to improve the status of HFMD and decreases the disease burden.

Indexed as

Enterovirus A, HumanHand, Foot and Mouth DiseaseVaccinationChildChild, PreschoolChinaCost-Benefit AnalysisFemaleHumansIncidenceInfantMaleEV71EV71 vaccinehand, foot and mouth diseasehealth economics evaluationvaccine

Identifiers

PMID40487526
PMCPMC12142048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.