ArticleiScience2025
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
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Authors and funding
11 authors.
Funding
Abstract
Dengue virus (DENV) is a mosquito-transmitted flavivirus; there are four serotypes (DENV1-4) that co-circulate globally. Primary infection causes self-limiting febrile illness, but secondary infection by a heterologous serotype can predispose to severe dengue. Neutralizing antibodies are key mediators of long-term protection; however, cross-reactive, non-neutralizing antibodies can cause antibody-dependent enhancement (ADE) of infection, which contributes to severe dengue. Therefore, elicitation of a potent, broadly neutralizing antibody response against all four DENV serotypes is desired for vaccine design. Here, we developed nanoparticle immunogens bearing engineered variants of the E glycoprotein DIII domain (DIII) in which epitopes targeted by non-neutralizing antibodies were mutated via structure-guided design and phage display. A two-component cocktail of these DIII variants elicited a broadly neutralizing response against all four DENV serotypes in mice and limited viremia in a DENV2 challenge model. These results provide insights into the design of broadly acting vaccines against DENV serotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.