Evidence map›Paper›PMID 40487398›Full record

ArticleFrontiers in pharmacology2025

Perioperative dexmedetomidine effects on delirium in elderly patients after noncardiac surgery: A retrospective propensity score analysis.

Hong-Wei Wang, Qin-Jun Chu, Ze-Fei Zhu, Ming Cheng, Ze-Ping Li, Liang Zang, Long He, Lin-Na Chen, Qian He, Jian-Jun Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hong-Wei Wang *Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qin-Jun Chu *Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Ze-Fei ZhuDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ming ChengDepartment of Medical Information, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ze-Ping LiDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liang ZangDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Long HeDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lin-Na ChenDepartment of Anesthesiology, The First Hospital of Jilin University, Changchun, China.
Qian HeDepartment of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Jian-Jun YangDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Han-Wen GuDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Delirium is a complex syndrome with limited pharmacological treatment options, whereas non-pharmacological prevention strategies warrant further investigation. Dexmedetomidine, an α2-adrenergic receptor agonist commonly used for sedation and analgesia, has shown potential anti-inflammatory effects that may contribute to delirium prevention. We conducted a retrospective PSM analysis to evaluate the effectiveness of dexmedetomidine in preventing postoperative delirium in elderly ICU patients undergoing noncardiac surgery. Methods: A retrospective analysis was conducted, including patients undergoing noncardiac surgeries after surgery. The main outcome was the 7-day incidence of delirium. Secondary outcomes included the length of hospital stay, postoperative nausea and vomiting, and postoperative complications. Propensity score matching and regression models were utilized to adjust for confounders and to investigate associations between the use of dexmedetomidine and outcomes. Results: A total of 19,899 patients were included, and 3,169 pairs were matched after propensity score matching. After matching, the incidence of postoperative delirium was 8.68% in the cohort with perioperative dexmedetomidine (test group) and 17.80% in the cohort without dexmedetomidine (control group), Conclusion: Perioperative infusion of dexmedetomidine may reduce the incidence of delirium in elderly patients after noncardiac surgery.

Indexed as

deliriumdexmedetomidineelderly patientsintensive care unitpostoperative nausea and vomitingpropensity score analysis postoperative deliriumpropensity score matching

Identifiers

PMID40487398
PMCPMC12141013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.