ReviewToxicology reports2025
Lead neurotoxicity in experimental models: A systematic review on effects on the cerebrum, cerebellum, and hippocampus.
Review in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Molecular and cellular mechanisms of lead-induced neurotoxicity: comparative insights from rodent and zebrafish models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Fermentation Status Dictates Organ-Selective Protection of a Millet-Based Dairy Beverage Against Sub-Chronic Lead Toxicity in Rats.Biological trace element research · 2026Article
- Caffeic Acid Mitigates Behavioral and Biochemical Alterations in Lead-induced Neurotoxicity in Rats With Possible Involvement of TFEB.Neurotoxicity research · 2026Article
- Perinatal exposure to metal mixtures disrupts neuronal function and behavior.Environmental research · 2026Article
- Endocrine-disrupting properties of heavy metal exposure contribute to the intergenerational effects on learning and memory.Frontiers in endocrinology · 2026Review
- Perinatal Exposure to Metal Mixtures Disrupts Neuronal Function and Behavior.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extensive use of heavy metals, such as lead, has resulted in environmental damage and numerous health problems in many parts of the world. Reports indicate that lead is the most significant toxic heavy metal with adverse impacts on several body systems. Primarily, lead targets the nervous system and causes a variety of neurological, motor, and behavioral deficits in humans and laboratory animals. Although several reports demonstrate the toxicity of lead, there is a paucity of comprehensive and updated reviews to highlight various histopathological findings on the effects of lead and its mechanisms of action on different brain structures; accordingly, this review was designed to address this gap. To achieve this, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) system was utilized, and prominent scientific databases, including Scopus, Web of Science, ResearchGate, Science Direct, Pubmed, and Google Scholar were searched to obtain information on the effects of lead and its mechanisms of action on different brain regions. Initially, 133 articles were obtained, but 60 articles satisfied the inclusion criteria and were selected for this review. These findings provide an updated compilation of lead toxicity and its mechanisms of action on different brain structures in experimental models. In addition, this review helps to advance the comprehension of lead poisoning and its harmful effects on the brain and may aid in the search for the development of novel therapeutic agents capable of mitigating lead toxicity and its associated neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.