Evidence map›Paper›PMID 40487351›Full record

ArticleMolecular therapy. Nucleic acids2025

Nanoparticle-formulated mRNA encoding engineered multivalent SIRPα-Fc fusion proteins shows robust anti-cancer activity in preclinical models.

Shruti Lal, Adrienne Sallets, Srinivasa R Bandi, Gowrisudha Adusumilli, Weiqun Liu, Ray Low, Kimmy Ferry, Chris MacDonough, Mahmoud ElAzzouny, Ole A W Haabeth and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shruti LalResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Adrienne SalletsResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Srinivasa R BandiResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Gowrisudha AdusumilliResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Weiqun LiuResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Ray LowResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Kimmy FerryResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Chris MacDonoughResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Mahmoud ElAzzounyResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Ole A W HaabethResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Colin J McKinlayResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Pei-Ken HsuResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Anushtha SharmaResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Pragyesh DhungelResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Jenna TriplettResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Meredith LeongResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Evan McCartney-MelstadResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Samuel DeutschResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.
Kannan GunasekaranResearch and Early Development, Nutcracker Therapeutics, Emeryville, CA 94608, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

antibody-dependent cellular cytotoxicityantibody-dependent cellular phagocytosisavidityCD47Fc fusion proteinslipid nanoparticlemRNAMT: Oligonucleotides: Therapies and ApplicationsmultivalentRaji xenograftSIRPα

Identifiers

PMID40487351
PMCPMC12141062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.