Evidence map›Paper›PMID 40487275›Full record

ArticleGastro hep advances2025

Lower Frequency of

Perapa Chotiprasidhi, Yvonne Ayerki Nartey, Karina Sato-Espinoza, Robert A Vierkant, Jun Ma, Yaw Awuku, Adwoa Agyei-Nkansah, Mary Afihene, Amoako Duah, Sally Bampoh and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Lower Allele Frequency ofJCO global oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Perapa ChotiprasidhiDivision of Gastroenterology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Yvonne Ayerki NarteyDepartment of Internal Medicine, Cape Coast Teaching Hospital, Cape Coast, Ghana.
Karina Sato-EspinozaDivision of Gastroenterology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Robert A VierkantDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Jun MaDivision of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester.
Yaw AwukuDepartment of Medicine and Therapeutics, School of Medicine, University of Health and Allied Sciences, Ho, Ghana.
Adwoa Agyei-NkansahDepartment of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana.
Mary AfiheneDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Amoako DuahDepartment of Medicine, University of Ghana Medical Centre, Legon, Ghana.
Sally BampohDepartment of Internal Medicine, Greater Accra Regional Hospital, Accra, Ghana.
Shadrack AsibeyDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Joshua AyawinDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Jun WangDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago.
Yinan ZhengDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago.
Claudia HawkinsInstitute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago.
Robert MurphyDepartment of Infectious Diseases, Center for Global Health, Chicago.
Godwin ImadeCollege of Health Sciences, University of Jos, Jos, Nigeria.
Edith OkekeCollege of Health Sciences, University of Jos, Jos, Nigeria.
Alani AkanmuLagos University Teaching Hospital and College of Medicine, University of Lagos, Lagos, Nigeria.
Olufunmilayo LesiLagos University Teaching Hospital and College of Medicine, University of Lagos, Lagos, Nigeria.
Amelie PlymothDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Jose D DebesDivision of Epidemiology and Community Health, Department of Medicine, School of Medicine, School of Public Health, University of Minnesota, Minneapolis.
Lewis R RobertsDivision of Gastroenterology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Samuel O AntwiDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida.
Kirk J WangensteenDivision of Gastroenterology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Hereditary Genetics of Hepatocellular CarcinomaR37CA259201 · NCI · MAYO CLINIC ROCHESTER · PI Kirk J Wangensteen · 2022 to 2026
$3.3M
NCI NIH HHS P30 CA015083NCI NIH HHS R37 CA259201
6 · The paper itself

Abstract

Background and Aims: The germline variant patatin-like phospholipase domain-containing protein 3 ( Methods: We enrolled 363 patients with HCC and 2807 cancer-free control patients from Ghana, Nigeria, and the U.S. Germline genetic sequencing was performed, and data on Results: There was a significantly lower frequency of the Conclusion: This study highlights the potential ancestral and global geographic differences in the genetic risk factors of HCC. It shows the population-specific variability in the association between

Indexed as

DisparityGenetic AncestryGenetic Association StudyPolygenic Risk Score

Identifiers

PMID40487275
PMCPMC12138894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.