ArticleGastro hep advances2025
Dupilumab Improves Histopathologic Features in Patients With Eosinophilic Esophagitis: LIBERTY EoE TREET Study Results.
Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Relationship Between Eosinophilic Esophagitis and Laryngeal Manifestations: Pathophysiology, Clinical Overlap, and Diagnostic Challenges.Journal of clinical medicine · 2026Review
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
- The Immune Architecture of Eosinophilic Esophagitis: Mechanisms, Therapeutic Targets, and Precision Management.ImmunoTargets and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Background and Aims: This post hoc analysis assessed the effect of dupilumab on the individual components of the Eosinophilic Esophagitis Histology Scoring System (EoEHSS) and the relationship between histopathologic and endoscopic measures in the LIBERTY eosinophilic esophagitis (EoE) TREET population. Methods: The analysis included patients who received dupilumab 300 mg weekly (qw) or placebo for 24 weeks (Parts A and B). Eligible patients who completed Parts A or B entered Part C and received dupilumab 300 mg qw for 28 weeks (week 52). Changes from baseline to week 24 and week 52 in the EoEHSS grade/stage components were assessed. Associations between histopathologic, symptomatic, and endoscopic features were evaluated using Spearman correlation. Results: At week 24, dupilumab improved most EoEHSS grade/stage component scores vs placebo. These improvements were sustained at week 52 in patients continuously on dupilumab; patients who switched from placebo to dupilumab at week 24 improved EoEHSS grade/stage component scores at week 52 to levels similar to those observed in patients continuously on dupilumab. Dupilumab also increased the proportion of patients in remission at week 24 vs placebo, with further increases at week 52, as assessed by the EoE histology remission score. EoEHSS grade and stage total scores correlated strongly with peak eosinophil count (PEC), moderately to strongly with Endoscopic Reference Score, and weakly with Dysphagia Symptom Questionnaire score. Several EoEHSS grade/stage component scores correlated strongly with PEC but not with Dysphagia Symptom Questionnaire scores. Conclusion: Dupilumab 300 mg qw improved histopathologic measures of EoE beyond PEC at week 24, with improvements sustained to week 52 (Video 1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.