ArticleComputational and structural biotechnology journal2025
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Exercise and Sports Metabolomics: Analytical Platforms, Metabolite Annotation, Pathway-Level Interpretation, and Biomarker-Panel Readiness.Metabolites · 2026Review
- Association Between Habitual Food Intake and Energy Metabolism-Related Urine Metabolites in Female Soccer Players.Molecular nutrition & food research · 2026Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Physical exercise induces various metabolic changes, influencing energy expenditure and substrate utilization. Metabolomics provides a comprehensive understanding of the metabolic adaptations occurring in response to physical exercise and recovery. This study aimed to investigate metabolic adaptations in recreational athletes by analyzing the urine metabolome following a high intensity interval training (HIIT) program with or without repeated cryotherapy recovery. Method: In this study, urine metabolomics with Results: PCA analysis revealed a distinct separation between the urine NMR profiles of the WBC and the CTL groups induced by SMC. Targeted analyses showed no significant metabolic differences before SMC. However, post-SMC analysis revealed marked changes in lactate, acetate, acetone, urea, formate, citrate and adenine levels. The training program amplified these metabolic alterations in both groups. The WBC group exhibited significant changes in alanine, acetone and 2-hydroxyisobutyric acid, while the CTL group showed alterations in citrate Conclusion: SMC triggers a variety of metabolic changes that reflect the body's efforts to maintain energy balance under stress. When combined with WBC, HIIT further enhances these adaptations, improving glycolytic capacity, fat metabolism, and the regulation of energy homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.