Evidence map›Paper›PMID 40487179›Full record

ArticleMaterials today. Bio2025

Oxygen-releasing microneedles enhance the therapeutic effect of corneal ectasia by increasing corneal oxygen content and riboflavin concentration during cross-linking.

Xueqi Lin, Wei Hu, Jiayue Yuan, Shichu Liu, Zhenghong Ge, Shangpeng Liu, Jing Cong, Qianhong Feng, Hao Li, Chenli Feng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xueqi LinDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wei HuDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Jiayue YuanDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shichu LiuDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhenghong GeDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Shangpeng LiuDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Jing CongDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Qianhong FengDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hao LiDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chenli FengDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Min SunDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Zhen FanDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Jinhui DaiDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal ectasia, characterized by progressive corneal thinning and reduced biomechanical properties, significantly impairs patients' visual quality. The epithelium-off (epi-off) procedure, the gold standard for treating corneal ectasia, avoids corneal transplantation but can cause pain and delayed healing. In contrast, trans-epithelial therapy preserves the epithelium but suffers from limited riboflavin penetration, reducing its efficacy. Furthermore, corneal cross-linking (CXL) is oxygen-dependent, and rapid oxygen depletion in the corneal stroma significantly limits the CXL efficacy. To alleviate oxygen deficiency in the corneal stroma during CXL, enhance riboflavin penetration, and reduce the side effects of epi-off therapy, novel oxygen-releasing riboflavin microneedles (O

Indexed as

Corneal cross-linkingCorneal ectasiaMicroneedlesOxygenRiboflavin

Identifiers

PMID40487179
PMCPMC12140951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.